The hemoglobin molecule, which is the oxygen carrier in blood, is present in all red blood cells (RBCs). Hemoglobinopathies are inherited disorders which result in the abnormal production or structure of the hemoglobin molecule. Sickle cell disease (SCD) and Thalassemia are types of blood disorders.
Sickle cell disease (SCD) is one such blood disorder caused by the abnormal hemoglobin that damages and deforms red blood cells.India is estimated to be home to over 50% of the world’s patients with SCD. The disease is most prevalent in tribal communities across the central Indian belt extending from south-eastern Gujarat to south-western Odisha.Over a million people have sickle cell disease in India today. There are nearly 2,00,000 babies born with the condition every year. Hence, it is important to screen the population for SCT to lower the prevalence of SCD.
Thalassemia is type of blood disorder that is caused by a defect in the gene that helps control the production of the globin chains that make up the hemoglobin molecule., if both parents have the thalassemia trait, the child can be born with thalassemia disease which is usually associated with severe illness, low quality of life, and premature death. Hence, it is important to screen the population for thalassemia trait.Individuals with the thalassemia trait are usually asymptomatic. However, if both parents have the thalassemia trait, the child can be born with thalassemia disease.
SickleFind is an absorbance spectrometry-based test for detecting the presence of sickle hemoglobin in blood. The test can be used to screen patients for sickle cell trait and sickle cell disease. The test gives results in 15 minutes. The test kit is used along with a compatible low-cost spectrometer to obtain the diagnosis. The test kit consists of a lysis buffer and a deoxygenation agent. The sample is mixed with the working buffer, incubated, and placed in the spectrometer to obtain the diagnosis. The test is easy to perform and only requires a couple of pipetting steps. All items required to perform the test are provided with the kit.
SickleCert is an absorbance spectrometry-based assay that can be used to rapidly distinguish between sickle cell disease and sickle cell trait. The performance of this simple and easy to use confirmatory test is comparable to the gold standard HPLC test. The test gives results in 15 minutes. The test kit is used along with a compatible low-cost spectrometer to obtain the diagnosis. The sample is mixed with the working buffer prepared using the test kit, incubated, and placed in the spectrometer to obtain the diagnosis. The test is easy to perform. All items required to perform the test are provided with the kit.
The diagnostic kit of 40 tests
Results available in 15 minutes
The kits are stable for 3 months
Room temperature storage
The test requires only 5 µl of patient blood
Absorbance-spectrometry based test